Study of the Immune Status of the Endometrium

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TIME is a comprehensive, effective and simple study of the immune status of the endometrium that can detect any immunological imbalance and indicate a personalized immunomodulatory treatment to each patient

“The immune system, a key factor in your fertility”

Currently, most cases of infertility are associated with known causes related to women’s reproductive health or men’s sperm quality, for which there are different treatments. However, despite the remarkable progress over the last years in diagnostic methods and assisted reproduction techniques that provide high-quality embryos, 15-30% of women around the world are unaware of the origin of their fertility, being diagnosed with idiopathic or unexplained infertility.
In these cases of idiopathic infertility, usually associated with repeated implantation failures or recurrent miscarriages, more and more professionals recommend a consultation with an immunologist. Latest studies reveal that in situations where all apparently known causes and existing treatments have been discarded, 8 out of 10 infertility cases are associated with an imbalance of the immune system.
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For this reason, the immunological factor turns out to be one of the fundamental physiological pillars in human reproduction, since the success of pregnancy depends on its correct balance. In this immunological aspect, the endometrium takes on great importance, a tissue that plays an indispensable role in embryo implantation and, therefore, in the achievement of a successful pregnancy.
During pregnancy, there is a constant flow of immune cells in the endometrium which are necessary for the proper formation of the placenta and fetal development. However, in altered immunological environments, these cells act in an opposite manner, recognizing the cells of the developing embryo as foreign and attacking them, which could lead to pregnancy problems.

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These altered immunological environments occur in situations in which the woman is going through some inflammatory process or is suffering from a specific disease, even if she has not yet manifested symptoms. In this aspect, the endometrium plays a crucial role, since it is able to detect if the woman’s organism is going through any of these situations and, therefore, is not prepared to develop and carry a pregnancy to term.
Due to these endometrial characteristics, it is essential to have a tool that, through the measurement of immunological parameters, can detect women’s health issues and, at the same time, help to successfully solve their infertility problems by the application of a personalized treatment.


This study only needs a blood sample and an endometrial biopsy to measure the following parameters:

Peripheral blood

• NK Cells: show cytotoxic activity and are responsible for identifying an destroying altered cells.
• LB1 Cells: helpful in autoimmunity screening.
• White blood cells: involved in protecting the body against both infectious disease and foreign invaders.

Endometrial biopsy

• NK uterine cells: show immunoregulatory activity and secrete factors that
promote placental development.

Time Pronacera Foto CelulaLikewise, this study offers the possibility of carrying out a KIR / HLA parental haplotype analysis. NK cells show membrane receptors called KIR that recognize and bind to HLA-C molecules (responsible for the recognition between self and non-self structures), located in the embryo’s membrane cells. The implantation of a semi-allogenic fetus (50% maternal 50%
paternal) in the maternal uterus is regulated by interactions of these KIR receptors with the HLA-C embryo molecules. Therefore, the predominant type of KIR receptors in women and the embryo HLA-C molecules are fundamental. The more different the HLA of the two members of the couple, the more likely it is that the immune system will detect the fetus as a stranger, giving rise to pregnancy problems.

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▪ The counting and typing of the different immune cells in the endometrial tissue is carried out by flow cytometry. This
technique allows us to differentiate cells based on their morphology and the presence of specific biomarkers.


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1. Overall view of the immunological status of the patient.
2. Detection of possible immunological alterations related to infertility.
3. Useful clinical data for the reproductive health of the patient and future search for motherhood.
4. Personalized immunomodulatory treatment. Based on the results provided by the TIME test, different treatments can be recommended to increase the chances of getting a successful pregnancy.

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